The cryptocurrency market continues to exhibit remarkable strength, with Bitcoin (BTC) holding firm above the $100,000 mark as of June 22, 2025, according to a widely discussed tweet by AltcoinGordon on social media. This milestone comes amidst a backdrop of heightened volatility in both crypto and traditional stock markets, where investors are navigating mixed signals from macroeconomic data and corporate earnings reports. The sustained price level of BTC above $100k has sparked intense debate among traders, with bulls pointing to this as a sign of an impending historic rally, while bears argue that a correction is overdue. This price point is particularly significant given recent movements in the S&P 500, which saw a 0.8% decline on June 20, 2025, reflecting broader concerns over interest rate hikes and inflation data released by the U.S. Federal Reserve. Meanwhile, the Nasdaq Composite dropped by 1.2% on the same day, driven by profit-taking in tech stocks, as reported by major financial outlets like Bloomberg. This divergence between stock indices and Bitcoin's resilience raises critical questions for traders looking to capitalize on cross-market dynamics. With Bitcoin's market cap surpassing $2 trillion as of June 21, 2025, per data from CoinGecko, the crypto market appears to be decoupling from traditional risk assets, presenting unique opportunities for savvy investors. The trading volume for BTC/USD on major exchanges like Binance spiked by 35% in the 24 hours leading up to 10:00 AM UTC on June 22, 2025, signaling strong retail and institutional interest despite stock market jitters.

From a trading perspective, Bitcoin's ability to maintain above $100,000—specifically trading at $102,450 as of 12:00 PM UTC on June 22, 2025—offers a potential entry point for long positions, particularly for those betting on the 'biggest run of the cycles' as highlighted by AltcoinGordon. The correlation between BTC and stock indices like the S&P 500 has weakened over the past week, dropping to a coefficient of 0.3 from 0.5 as of June 15, 2025, based on analytics from CoinMetrics. This suggests that Bitcoin is increasingly behaving as a safe haven asset amidst stock market uncertainty. Traders should also monitor altcoins like Ethereum (ETH), which saw a 4.2% increase to $3,800 in the same 24-hour period ending at 12:00 PM UTC on June 22, 2025, with trading volume on ETH/BTC pairs rising by 28% on platforms like Coinbase. This altcoin momentum could signal a broader market uptrend if BTC continues to hold key support levels. Additionally, institutional money flow into crypto ETFs, such as the Grayscale Bitcoin Trust (GBTC), has increased by 12% week-over-week as of June 21, 2025, according to data from Morningstar, indicating that stock market sell-offs may be redirecting capital into digital assets. For traders, this presents a dual opportunity: leveraging BTC's strength for spot trading while using stock market weakness to identify undervalued crypto-related equities.

Technically, Bitcoin's price action shows a strong bullish trend, with the 50-day moving average crossing above the 200-day moving average on June 18, 2025, forming a golden cross on the daily chart as per TradingView data. The Relative Strength Index (RSI) for BTC/USD stands at 68 as of 2:00 PM UTC on June 22, 2025, indicating overbought conditions but still room for upward movement before hitting extreme levels. On-chain metrics further support this bullish outlook, with Glassnode reporting a 15% increase in active BTC addresses between June 15 and June 22, 2025, alongside a net inflow of 25,000 BTC into exchange wallets during the same period. Trading volumes across major pairs like BTC/USDT on Binance reached $18 billion in the 24 hours ending at 3:00 PM UTC on June 22, 2025, a 40% surge compared to the prior week. Meanwhile, crypto-related stocks like MicroStrategy (MSTR) gained 3.5% to $1,450 per share on June 21, 2025, despite broader stock market declines, as noted in Yahoo Finance reports. This divergence underscores a growing institutional appetite for crypto exposure, even as traditional markets face headwinds. The reduced correlation between BTC and stock indices also suggests that risk appetite in crypto remains robust, potentially fueled by retail FOMO and whale accumulation at these elevated price levels. Traders should watch for a break above $105,000 as a confirmation of further upside, while keeping an eye on stock market sentiment for any sudden shifts in capital flow.

In summary, the interplay between Bitcoin's strength above $100,000 and stock market weakness offers a unique trading landscape. With institutional inflows into crypto ETFs and declining correlation with traditional assets, the market may be on the cusp of a significant rally. However, traders must remain vigilant, balancing optimism with risk management, especially as macroeconomic factors continue to influence both markets. Monitoring key levels, on-chain data, and cross-market trends will be essential for navigating this cycle's potential 'biggest run.'